cerebral cortex

[키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model animal models Asymptomatic Author both groups Brain cerebral cortex chemokines clinical manifestation Course COVID-19 COVID-19 pandemic COVID-19 pathogenesis cytokeratin 18 promoter develop disease disease course disease manifestation dose-dependent DPI etiological agent expressing Extrapulmonary hACE2 hippocampus Human human SARS-CoV-2 humanized immunological disease immunological diseases in both group Infection infectious virus titer inoculated inoculation interstitial pneumonia intestinal tract K18 K18-hACE2 mice lethal disease low dose Lower respiratory tract lung Lungs lymphocyte lymphocyte infiltration Macrophage mice Mild mild to moderate moderate disease nasal turbinates Pathogenesis pathology patients Pneumocytes post inoculation progression proinflammatory Pulmonary pathology rapid inflammatory response receptor replication of SARS-CoV-2 reported respiratory Respiratory disease respiratory tract infection resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Severe case severe cases severe COVID-19 subset Support survival susceptible TCID Th1 Th1 and proinflammatory cytokines/chemokines the SARS-CoV-2 These data Trachea transgenic mice upper and lower respiratory tract upper and lower respiratory tract infection upregulation Viral Viral RNA shedding virus replication virus titers weight loss while
[DOI] 10.1371/journal.ppat.1009195 PMC 바로가기 [Article Type] Research Article